The efficacy of Infulgan in perioperative pain management in oncology

Clinical Oncology Center, Dnipropetrovsk (Dnipro)

Annually, approximately 170,000 people in Ukraine are newly diagnosed with malignancies. Subsequently, 32.5% of them are subjected to combined or multimodal therapy, and 35.3% of patients receive only surgical treatment, which requires postoperative pain relief. Special aspects about patients with cancer are that in most cases they are elderly people, who have a range of chronic conditions, as well as that the underlying disease and chemotherapy and radiation therapy, given before surgery (neoadjuvant), cause homeostatic disorders, requiring a careful approach to the choice of pain management methods in the postoperative period. postoperative pain relief remains an important issue. Currently, about one third of patients after surgery, despite the given analgesia, indicate pain of varying severity. However, ongoing replenishment of the analgesics arsenal with new agents still does not resolve the problem.

Obviously, there is a need in the strategies of postoperative pain management that take into account the pathophysiology of pain, the general condition of the patient, characteristics of the pharmacological profile of drugs, the possibility of combining different methods in order to improve the quality of the postoperative period course.

At present, this approach has been implemented in the concept of multimodal analgesia, involving a combination of various means and methods of anesthesia. By influencing the various links in nociception, it is feasible to achieve a more pronounced analgesic effect with lower doses of the administered agents, and, consequently, to reduce the severity of their adverse effects.

Paracetamol is a medicinal product with proven efficacy and safety, which is recommended for the application by international guidelines, such as the Acute Pain Management: Scientific Evidence (2005), Postoperative Pain Management — Good Clinical Practice (2005).

With Infulgan (YURiA-PHARM) becoming commercially available in Ukraine, it is now possible to use the infusion form of paracetamol as a component of multimodal analgesia after abdominal surgery.

The aim of the study was to evaluate the efficacy of paracetamol as a solution for intravenous infusion as a component of postoperative pain relief after abdominal surgeries in oncology.